ea0070aep1093 | Hot topics (including COVID-19) | ECE2020
Pani Fabiana
, Yasuda Yoshinori
, Di Dalmazi Giulia
, Gabrielson Kathleen
, Chalan Paulina
, Mariotti Stefano
, Caturegli Patrizio
The relationship between papillary thyroid cancer (PTC) and autoimmune thyroiditis remains controversial. To gain mechanistic insights, we developed a mouse model by combining three strains: BRAFv600E knock-in and TPO-CRE-ER transgenic to induce PTC upon tamoxifen injection, and NOD.H2h4 congenic to induce thyroiditis upon iodine administration.A total of 113 mice of the desired genotype (BRAF mutant homozygous, CRE transgenic hemiz...